Clinical Evidence for a BALIMONT Multi-Strain Oral Probiotic Composition in Enhancing Skin Radiance

Anas Ziraoui; Antonio Bellini; Troy Maddox

doi:10.54691/4sh99208

Authors

Anas Ziraoui
Antonio Bellini
Troy Maddox

DOI:

https://doi.org/10.54691/4sh99208

Keywords:

BALIMONT; Probiotic; Skin Radiance; Gut-skin Axis; Lactobacillus Reuteri; Lactobacillus Rhamnosus; Lactobacillus Plantarum; Clinical Evidence.

Abstract

We evaluated a BALIMONT multi-strain oral probiotic composition for improvement of visible skin radiance and interpreted the 28-day cohort findings against published human clinical trials of oral probiotics and synbiotics relevant to skin appearance. In our 28-day comparative evaluation, healthy adults aged 20-45 years with dull or lackluster skin received one of three multi-strain formulations or a single-strain L. reuteri comparator, with 30 participants in each cohort. At day 28, mean radiance improvement reached 14.2%, 10.8%, and 11.5% in the three multi-strain cohorts, versus 2.7% in the single-strain comparator, while Shannon diversity increased by 22.6%, 18.3%, and 19.1% versus 5.2%, respectively. Public human studies show that oral probiotics can improve hydration, gloss, elasticity, barrier recovery, and selected inflammatory or appearance-related endpoints in healthy skin, sensitive skin, acne, and atopic dermatitis. Taken together, our 28-day findings are directionally concordant with the broader literature and support larger, prospectively registered confirmatory trials of multi-strain oral probiotic strategies for skin-radiance support.

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References

[1] Lee DE, Huh C-S, Ra J, Choi I-D, Jeong J-W, Kim S-H, et al. Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study. J Microbiol Biotechnol. 2015;25(12):2160-2168. doi:10.4014/jmb.1509.09021.

[2] Kano M, Masuoka N, Kaga C, Sugimoto S, Iizuka R, Manabe K, et al. Consecutive Intake of Fermented Milk Containing Bifidobacterium breve Strain Yakult and Galacto-oligosaccharides Benefits Skin Condition in Healthy Adult Women. Biosci Microbiota Food Health. 2013;32(1):33-39. doi:10.12938/bmfh.32.33.

[3] Gueniche A, Philippe D, Bastien P, Reuteler G, Blum S, Castiel-Higounenc I. Randomised Double-blind Placebo-controlled Study of the Effect of Lactobacillus paracasei NCC 2461 on Skin Reactivity. Benef Microbes. 2014;5(2):137-145. doi:10.3920/BM2013.0001.

[4] Michelotti A, Cestone E, De Ponti I, Giardina S, Pisati M, Sparta E, et al. Efficacy of a Probiotic Supplement in Patients with Atopic Dermatitis: A Randomized, Double-blind, Placebo-controlled Clinical Trial. Eur J Dermatol. 2021;31(2):225-232. doi:10.1684/ejd.2021.4019.

[5] Rinaldi F, Marotta L, Mascolo A, Amoruso A, Pane M, Giuliani G, et al. Facial Acne: A Randomized, Double-blind, Placebo-controlled Study on the Clinical Efficacy of a Symbiotic Dietary Supplement. Dermatol Ther (Heidelb). 2022;12(2):577-589. doi:10.1007/s13555-021-00664-z.

[6] Eguren C, Navarro-Blasco A, Corral-Forteza M, Reolid-Perez A, Seto-Torrent N, Garcia-Navarro A, et al. A Randomized Clinical Trial to Evaluate the Efficacy of an Oral Probiotic in Acne Vulgaris. Acta Derm Venereol. 2024;104:adv33206. doi:10.2340/actadv.v104.33206.

[7] Lin H-W, Tam K-W, Huang Y-C. Efficacy of Oral Probiotics in Patients with Acne: A Systematic Review and Meta-analysis of Randomized Trials. Clin Exp Dermatol. 2025;51(1):68-77. doi:10.1093/ced/llaf388.

[8] Theodorou IM, Kapoukranidou D, Theodorou M, Tsetis JK, Menni AE, Tzikos G, et al. Cosmeceuticals: A Review of Clinical Studies Claiming to Contain Specific, Well-Characterized Strains of Probiotics or Postbiotics. Nutrients. 2024;16(15):2526. doi:10.3390/nu16152526.